In view of the industrial wastewater difficult to biodegrade, especially high content of inorganic salt, high content of refractory organic compounds, or inorganic salt content and refractory organic matter content high chemical and pharmaceutical wastewater, Moosechem technology developed a unique integrated membrane treatment technology: with nanofiltration membrane as the core technology of inorganic salt and/or refractory organic matter enrichment and separation, combined with pretreatment, physical-chemical treatment, the MBR or ultrafiltration pre-filtering, biochemical treatment system, technological means such as wet oxidation system, achieve difficult biological treatment of industrial wastewater and water reuse.